Furthermore, as approximately 50% of all retinal ganglion cells are sited within 10 degrees of the fovea, presuming an absence of macular co-morbidities, changes in macular structure are likely to be a good indication of glaucoma-related neural losses. The macula is essential for good central vision and therefore glaucomatous changes in this region may have particularly serious consequences for vision related quality of life and daily function. Īlthough cpRNFL thinning is a useful marker of glaucomatous damage, there is growing recognition that measurement of the glaucomatous macula may also reveal changes that could potentially aid diagnosis. It has been shown that circumpapillary retinal nerve fiber layer (cpRNFL) measurements from OCT have good ability to differentiate glaucomatous and healthy eyes with AUC ranging from 0.728 to 0.969. Recent advances in imaging technologies, especially the development of optical coherence tomography (OCT), provide a means for the objective evaluation of structural changes to the optic nerve head and retina in glaucoma, and offer the potential for improved detection of disease. As glaucomatous visual loss is irreversible, early diagnosis is important however, this can be challenging due to large inter-individual variation in normal disc appearance, inter-observer differences in disc evaluation, and lack of sensitivity of visual field testing due to physiological redundancy in retinal ganglion cell receptive fields. The diagnosis of glaucoma in clinical practice largely depends on identification of characteristic structural changes to the optic nerve head, which are often accompanied by functional deficits on visual field testing. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. AJT is a consultant to Heidelberg Engineering (Heidelberg, Germany). FAM has received research support from Topcon, Inc. RNW and FAM are consultants to Carl-Zeiss Meditec. RNW receives resource support from Optovue (Fremont, California). LMZ, RNW, FAM receive research support from Carl-Zeiss Meditec (Dublin, California) Heidelberg Engineering (Heidelberg, Germany) and Topcon (Tokyo, Japan). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: Funding came from the National Institutes of Health/National Eye Institute grants ( ): EY021818 (F.A.M.), EY11008 (L.M.Z.), EY14267 (L.M.Z.), EY019869 (L.M.Z.), and core grant P30EY022589.Ĭompeting interests: The authors ZY and TL have declared that no competing interests exist. Received: OctoAccepted: MaPublished: May 15, 2015Ĭopyright: © 2015 Yang et al. PLoS ONE 10(5):Īcademic Editor: Rafael Linden, Universidade Federal do Rio de Janeiro, BRAZIL Citation: Yang Z, Tatham AJ, Weinreb RN, Medeiros FA, Liu T, Zangwill LM (2015) Diagnostic Ability of Macular Ganglion Cell Inner Plexiform Layer Measurements in Glaucoma Using Swept Source and Spectral Domain Optical Coherence Tomography.

Plexiform layers